The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency

S Bulk; J Berkhof; L Rozendaal; N C Fransen Daalmeijer; M Gök; F A de Schipper; F J van Kemenade; P J F Snijders; C J L M Meijer

doi:10.1038/sj.bjc.6603693

The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency

Br J Cancer. 2007 Apr 23;96(8):1234-6. doi: 10.1038/sj.bjc.6603693. Epub 2007 Mar 20.

Authors

S Bulk¹, J Berkhof, L Rozendaal, N C Fransen Daalmeijer, M Gök, F A de Schipper, F J van Kemenade, P J F Snijders, C J L M Meijer

Affiliation

¹ Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.

Abstract

In one geographical area, 14 high-risk human papillomavirus types in cervical intraepithelial neoplasia (CIN2/3; n=139) and cervical squamous cell carcinoma (SCC; n=84) were analysed. HPV18 was more prevalent in SCC than CIN2/3 (OR 9.8; 95% confidence interval: 2.5-39). Other high-risk types prevalences corresponded in CIN2/3 and SCC. Evaluations using CIN2/3 as a measure of efficiency underestimate the contribution of HPV18 to SCC.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell / virology*
Cross-Sectional Studies
Female
Human papillomavirus 18 / isolation & purification*
Humans
Middle Aged
Uterine Cervical Dysplasia / virology*
Uterine Cervical Neoplasms / virology*