2-Methylisoborneol (MIB) and geosmin (GSM) are taste and odor compounds produced by cyanobacteria in surface waters. While the strong odors and musty flavors of MIB and GSM are generally associated with poor water quality, the removal of these semi-volatile compounds presents a significant challenge to drinking water providers. Likewise in aquaculture, accumulation of these compounds in fish meat leads to quality problems and reduces marketability. Conventional water treatments are ineffective at removing low concentration of odor compounds. We report herein ultrasonic irradiation at 640 kHz leads to rapid degradation of MIB and GSM. While radical processes generally dominate during ultrasonic-induced degradation, pyrolysis appears to be responsible for a significant fraction of the observed degradation. Several pyrolytic products from MIB and GSM have been identified and degradation pathways are elucidated. The degradation of MIB and GSM follows the first-order kinetics and the rate constants are 0.07 and 0.12 min(-1), respectively. These results suggest ultrasonic irradiation maybe applicable as an effective method for removal of taint compounds from potable water supplies and fish farms.