Abstract
A 38-year-old man developed the Guillain-Barré syndrome (GBS) associated with untreated end-stage AIDS and CD4+ lymphocyte count of 3 cells/mm(3). The patient had serum high titer anti-sulfatide antibodies and responded well to infusion of immunoglobulin. The data suggest that elevated levels of anti-sulfatide antibodies may play a role in the pathogenesis of GBS in this patient, although a direct neurotropic effect of HIV virus cannot be excluded.
Publication types
-
Case Reports
-
Research Support, N.I.H., Extramural
MeSH terms
-
Acquired Immunodeficiency Syndrome / complications*
-
Acquired Immunodeficiency Syndrome / pathology*
-
Adult
-
Antibodies / blood*
-
CD4-Positive T-Lymphocytes / physiology*
-
Chromatography, Thin Layer / methods
-
Enzyme-Linked Immunosorbent Assay / methods
-
Guillain-Barre Syndrome / complications*
-
Guillain-Barre Syndrome / pathology*
-
Humans
-
Male
-
Neural Conduction / physiology
-
Peripheral Nerves / physiopathology
-
Sulfoglycosphingolipids / immunology*
Substances
-
Antibodies
-
Sulfoglycosphingolipids