Elevated anti-sulfatide antibodies in Guillain-Barré syndrome in T cell depleted at end-stage AIDS

J Neuroimmunol. 2007 Aug;188(1-2):143-5. doi: 10.1016/j.jneuroim.2007.05.020. Epub 2007 Jun 28.

Abstract

A 38-year-old man developed the Guillain-Barré syndrome (GBS) associated with untreated end-stage AIDS and CD4+ lymphocyte count of 3 cells/mm(3). The patient had serum high titer anti-sulfatide antibodies and responded well to infusion of immunoglobulin. The data suggest that elevated levels of anti-sulfatide antibodies may play a role in the pathogenesis of GBS in this patient, although a direct neurotropic effect of HIV virus cannot be excluded.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Acquired Immunodeficiency Syndrome / pathology*
  • Adult
  • Antibodies / blood*
  • CD4-Positive T-Lymphocytes / physiology*
  • Chromatography, Thin Layer / methods
  • Enzyme-Linked Immunosorbent Assay / methods
  • Guillain-Barre Syndrome / complications*
  • Guillain-Barre Syndrome / pathology*
  • Humans
  • Male
  • Neural Conduction / physiology
  • Peripheral Nerves / physiopathology
  • Sulfoglycosphingolipids / immunology*

Substances

  • Antibodies
  • Sulfoglycosphingolipids