To investigate the association between social support and depression in Parkinson's disease (PD), 121 PD patients were enrolled in our study. Interview of questionnaires and neurological examinations, including Hamilton Depression Rating Scale, Chinese Social Support Rating Scale (SSRS), Hoehn and Yahr Stage, Schwab and England Scale (SE) and unified PD Rating Scale (UPDRS) were performed. Increased level of UPDRS and lowered social support were associated with depression in PD patients. Stepwise regression analysis showed that objective social support, UPDRS part 1 and duration of disease manifested significant correlation to patients' depression degree. Therefore, social support plays an important role in depression in PD.