Abstract
We studied three vitamin D receptor gene (VDR) polymorphisms (BsmI, TaqI, FokI) in a case-control study of non-Hodgkin's lymphoma. The BsmI B and TaqI t alleles were associated with an increased risk of diffuse large B-cell lymphoma. These findings suggest that variants in VDR may influence lymphomagenesis.
Publication types
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Letter
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Multicenter Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Case-Control Studies
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Deoxyribonucleases, Type II Site-Specific
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Genetic Predisposition to Disease
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Humans
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Lymphoma, Non-Hodgkin / classification
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Lymphoma, Non-Hodgkin / epidemiology
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Lymphoma, Non-Hodgkin / genetics*
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New South Wales / epidemiology
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Polymorphism, Restriction Fragment Length*
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Polymorphism, Single Nucleotide*
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Receptors, Calcitriol / genetics*
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Risk
Substances
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Receptors, Calcitriol
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endodeoxyribonuclease BsmI
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endodeoxyribonuclease FokI
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Deoxyribonucleases, Type II Site-Specific
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TCGA-specific type II deoxyribonucleases