Vitamin D receptor gene polymorphisms and risk of non-Hodgkin's lymphoma

Haematologica. 2007 Aug;92(8):1145-6. doi: 10.3324/haematol.11053.

Abstract

We studied three vitamin D receptor gene (VDR) polymorphisms (BsmI, TaqI, FokI) in a case-control study of non-Hodgkin's lymphoma. The BsmI B and TaqI t alleles were associated with an increased risk of diffuse large B-cell lymphoma. These findings suggest that variants in VDR may influence lymphomagenesis.

Publication types

  • Letter
  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Deoxyribonucleases, Type II Site-Specific
  • Genetic Predisposition to Disease
  • Humans
  • Lymphoma, Non-Hodgkin / classification
  • Lymphoma, Non-Hodgkin / epidemiology
  • Lymphoma, Non-Hodgkin / genetics*
  • New South Wales / epidemiology
  • Polymorphism, Restriction Fragment Length*
  • Polymorphism, Single Nucleotide*
  • Receptors, Calcitriol / genetics*
  • Risk

Substances

  • Receptors, Calcitriol
  • endodeoxyribonuclease BsmI
  • endodeoxyribonuclease FokI
  • Deoxyribonucleases, Type II Site-Specific
  • TCGA-specific type II deoxyribonucleases