Epicoccins A-D, epipolythiodioxopiperazines from a Cordyceps-colonizing isolate of Epicoccum nigrum

Yonggang Zhang; Shuchun Liu; Yongsheng Che; Xingzhong Liu

doi:10.1021/np070239u

Epicoccins A-D, epipolythiodioxopiperazines from a Cordyceps-colonizing isolate of Epicoccum nigrum

J Nat Prod. 2007 Sep;70(9):1522-5. doi: 10.1021/np070239u. Epub 2007 Aug 22.

Authors

Yonggang Zhang¹, Shuchun Liu, Yongsheng Che, Xingzhong Liu

Affiliation

¹ Key Laboratory of Systematic Mycology and Lichenology, and Center for Bio-Energy and Industrial Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100080, People's Republic of China.

PMID: 17711348
DOI: 10.1021/np070239u

Abstract

Epicoccins A-D (1-4), four unique epipolythiodioxopiperazines possessing unusual sulfur bridges, have been isolated from cultures of a Cordyceps-colonizing isolate of Epicoccum nigrum. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data. The relative and absolute configuration of epicoccin A (1) was established by single-crystal X-ray diffraction analysis. Epicoccin A (1) showed modest antimicrobial activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / chemistry
Anti-Infective Agents / isolation & purification*
Anti-Infective Agents / pharmacology
Ascomycota / chemistry*
Cordyceps / chemistry
Crystallography, X-Ray
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Piperazines / chemistry
Piperazines / isolation & purification*
Piperazines / pharmacology
Tibet

Substances

Anti-Infective Agents
Piperazines