Abstract
Gliocladinins A (1) and B (2), two new p-terphenyl derivatives, have been isolated from solid cultures of an isolate of Gliocladium sp. that colonizes Cordyceps sinensis. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data. In standard disk assays, compounds 1 and 2 showed modest antimicrobial activity against Staphylococcus aureus (ATCC 6538). In addition, these compounds displayed inhibitory effects on the growth of two human tumor cell lines, HeLa and HCT116.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Cordyceps
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Drug Screening Assays, Antitumor
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Gliocladium / chemistry*
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HeLa Cells
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Humans
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Microbial Sensitivity Tests
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Molecular Structure
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Staphylococcus aureus / drug effects*
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Terphenyl Compounds / chemistry
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Terphenyl Compounds / isolation & purification*
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Terphenyl Compounds / pharmacology
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Tibet
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Antineoplastic Agents
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Terphenyl Compounds
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gliocladinin A
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gliocladinin B