Positive association between OLIG2 and schizophrenia in the Chinese Han population

Hum Genet. 2008 Jan;122(6):659-60. doi: 10.1007/s00439-007-0434-z. Epub 2007 Oct 13.

Abstract

A recent study reported that OLIG2 had a significant association with schizophrenia in the UK population. We genotyped three variants scattered among the genomic region of OLIG2, namely rs1005573, rs762178 and rs1059004 in a sample consisting of 329 schizophrenia patients and 288 controls. The results provide further evidence that the SNP rs762178 in OLIG2 seems to be a potential candidate in altering risk for schizophrenia in the Chinese Han population and worthy of further replication and functional study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asian People / genetics*
  • Basic Helix-Loop-Helix Transcription Factors / genetics*
  • Case-Control Studies
  • Female
  • Genetic Linkage
  • Genetics, Population
  • Humans
  • Male
  • Middle Aged
  • Nerve Tissue Proteins / genetics*
  • Oligodendrocyte Transcription Factor 2
  • Polymorphism, Single Nucleotide
  • Schizophrenia / genetics*

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • Nerve Tissue Proteins
  • OLIG2 protein, human
  • Oligodendrocyte Transcription Factor 2