Clustering of individuals given SNPs similarity based on normalized mutual information: F7 SNPs in the GAIT sample

Annu Int Conf IEEE Eng Med Biol Soc. 2007:2007:123-6. doi: 10.1109/IEMBS.2007.4352238.

Abstract

This paper proposes the clustering of individuals given their genotype using a normalized Mutual Information dissimilarity distance. This method is applied to a Single Nucleotyde Polymorphism set belonging to F7 gene, uncovering the intrinsic genetic variability on one Spanish population. This genetic variability corresponds to results published using a complete different approach in population genetics literature. Identified groups are shown to express significant differences in the level of FVII concentration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Cluster Analysis
  • Factor VII / genetics*
  • Genotype
  • Humans
  • Polymorphism, Single Nucleotide
  • Thrombophilia / genetics*

Substances

  • Factor VII