The effect of flavonoid derivatives on doxorubicin transport and metabolism

Radka Václavíková; Eliska Kondrová; Marie Ehrlichová; Ahcene Boumendjel; Jan Kovár; Pavel Stopka; Pavel Soucek; Ivan Gut

doi:10.1016/j.bmc.2007.10.093

The effect of flavonoid derivatives on doxorubicin transport and metabolism

Bioorg Med Chem. 2008 Feb 15;16(4):2034-42. doi: 10.1016/j.bmc.2007.10.093. Epub 2007 Nov 4.

Authors

Radka Václavíková¹, Eliska Kondrová, Marie Ehrlichová, Ahcene Boumendjel, Jan Kovár, Pavel Stopka, Pavel Soucek, Ivan Gut

Affiliation

¹ Group for Biotransformations, Center of Occupational Medicine, National Institute of Public Health, Srobarova 48, 100 42 Prague 10, Czech Republic.

PMID: 18024139
DOI: 10.1016/j.bmc.2007.10.093

Abstract

This study investigated the effect of naturally occurring flavonoids and synthetic aurone derivatives on the formation of cardiotoxic doxorubicinol and transport of doxorubicin in breast cancer cells. Quercetin significantly inhibited the formation of doxorubicinol. Quercetin and aurones did not significantly affect transport of [14C]doxorubicin in human resistant breast cancer cells. In conclusion, quercetin should be further tested for its potency to decrease doxorubicin-mediated toxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibiotics, Antineoplastic
Benzofurans / pharmacology
Biological Transport / drug effects
Breast Neoplasms
Cell Line, Tumor
Doxorubicin / analogs & derivatives
Doxorubicin / metabolism*
Doxorubicin / pharmacokinetics*
Female
Flavonoids / chemistry
Flavonoids / pharmacology*
Humans
Metabolism / drug effects
Quercetin / pharmacology

Substances

Antibiotics, Antineoplastic
Benzofurans
Flavonoids
aurone
Doxorubicin
Quercetin
adriamycinol