Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis

Antimicrob Agents Chemother. 2008 Feb;52(2):735-8. doi: 10.1128/AAC.00990-07. Epub 2007 Dec 10.

Abstract

Synergistic interactions were observed between CIs and antifungal agents against 53 (90%) of 59 Cryptococcus neoformans isolates from solid organ transplant recipients with cryptococcosis and may account for better outcomes in patients with cryptococcosis receiving these immunosuppressive agents.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Antifungal Agents / therapeutic use
  • Calcineurin Inhibitors*
  • Cryptococcosis / drug therapy*
  • Cryptococcosis / microbiology
  • Cryptococcus neoformans / drug effects*
  • Drug Synergism
  • Humans
  • Immunosuppressive Agents / pharmacology*
  • Immunosuppressive Agents / therapeutic use
  • Microbial Sensitivity Tests
  • Organ Transplantation / adverse effects*
  • Tacrolimus / pharmacology*
  • Tacrolimus / therapeutic use
  • Treatment Outcome

Substances

  • Antifungal Agents
  • Calcineurin Inhibitors
  • Immunosuppressive Agents
  • Tacrolimus