Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects

Kazuaki Miyake; Yukio Horikawa; Kazuo Hara; Kazuki Yasuda; Haruhiko Osawa; Hiroto Furuta; Yushi Hirota; Kazuya Yamagata; Yoshinori Hinokio; Yoshitomo Oka; Naoko Iwasaki; Yasuhiko Iwamoto; Yuichiro Yamada; Yutaka Seino; Hiroshi Maegawa; Atsunori Kashiwagi; Ken Yamamoto; Katsushi Tokunaga; Jun Takeda; Hideichi Makino; Kishio Nanjo; Takashi Kadowaki; Masato Kasuga

doi:10.1007/s10038-007-0231-5

Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects

J Hum Genet. 2008;53(2):174-180. doi: 10.1007/s10038-007-0231-5. Epub 2007 Dec 21.

Authors

Kazuaki Miyake¹, Yukio Horikawa^{2

3}, Kazuo Hara⁴, Kazuki Yasuda⁵, Haruhiko Osawa⁶, Hiroto Furuta⁷, Yushi Hirota¹, Kazuya Yamagata⁸, Yoshinori Hinokio⁹, Yoshitomo Oka⁹, Naoko Iwasaki¹⁰, Yasuhiko Iwamoto¹⁰, Yuichiro Yamada^{11

12}, Yutaka Seino^{13

12}, Hiroshi Maegawa¹⁴, Atsunori Kashiwagi¹⁴, Ken Yamamoto¹⁵, Katsushi Tokunaga¹⁶, Jun Takeda², Hideichi Makino⁶, Kishio Nanjo⁷, Takashi Kadowaki⁴, Masato Kasuga¹⁷

Affiliations

¹ Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
² Department of Diabetes and Endocrinology Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan.
³ Laboratory of Medical Genomics, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
⁴ Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
⁵ Department of Metabolic Disorder, Research Institute, International Medical Center of Japan, Tokyo, Japan.
⁶ Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
⁷ The First Department of Medicine, Wakayama Medical University, Wakayama, Japan.
⁸ Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
⁹ Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan.
¹⁰ Department of Medicine, Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan.
¹¹ Department of Internal Medicine, Akita University School of Medicine, Akita, Japan.
¹² Department of Diabetes and Clinical Nutrition, Kyoto University School of Medicine, Kyoto, Japan.
¹³ Kansai Electric Power Hospital, Osaka, Japan.
¹⁴ Division of Endocrinology and Metabolism Department of Medicine, Shiga University of Medical Science, Shiga, Japan.
¹⁵ Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
¹⁶ Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
¹⁷ Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. kasuga@med.kobe-u.ac.jp.

PMID: 18097733
DOI: 10.1007/s10038-007-0231-5

Abstract

Transcription factor 7-like 2 (TCF7L2) has been shown to be associated with type 2 diabetes mellitus in multiple ethnic groups. Regarding the Asian population, Horikoshi et al. (Diabetologia 50:747-751, 2007) and Hayashi et al. (Diabetologia 50:980-984, 2007) reported that single nucleotide polymorphisms (SNPs) in TCF7L2 were associated with type 2 diabetes in the Japanese population, while contradictory results were reported for Han Chinese populations. The aim of this study was to investigate the associations of the TCF7L2 gene with type 2 diabetes using a relatively large sample size: 2,214 Japanese individuals with type 2 diabetes and 1,873 normal controls. The minor alleles of rs7903146, rs11196205, and rs12255372 showed significant associations with type 2 diabetes (OR=1.48, P=2.7 x 10(-4); OR=1.39, P=4.6 x 10(-4); OR=1.70, P=9.8 x 10(-5), respectively) in the combined sample sets. However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population.

Publication types

Comparative Study
Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alleles
Case-Control Studies
Diabetes Mellitus, Type 2 / epidemiology
Diabetes Mellitus, Type 2 / genetics*
Female
Genetic Predisposition to Disease*
Genotype
Haplotypes / genetics
Humans
Japan / epidemiology
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Risk Factors
TCF Transcription Factors / genetics*
Transcription Factor 7-Like 2 Protein

Substances

TCF Transcription Factors
TCF7L2 protein, human
Transcription Factor 7-Like 2 Protein