Phenoxymethylpenicillin two or three times daily in bacterial upper respiratory tract infections: a blinded, randomized and controlled clinical study

Scand J Infect Dis. 1991;23(6):755-61. doi: 10.3109/00365549109024304.

Abstract

In relation to compliance problems it was investigated whether phenoxymethylpenicillin dosed 2 or 3 times daily was equally effective in bacterial upper respiratory infections. In a randomized, controlled and single blind clinical trial, 131 patients with otitis media, sinusitis and tonsillitis were treated with phenoxymethylpenicillin. 71 received the daily dose twice a day and 60 patients received the daily dose 3 times a day. The dose was adjusted for diagnoses and age. Clinical cure was the endpoint for treatment success. In the 2-dosage group 78.6% had full effect of the treatment and 86.2% had full effect in the 3-dosage group. There was no statistically significant difference. In conclusion phenoxymethylpenicillin dosed 2 or 3 times daily seems to be equally effective in bacterial upper respiratory infection.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Infections / drug therapy*
  • Child
  • Child, Preschool
  • Drug Administration Schedule
  • Female
  • Humans
  • Infant
  • Male
  • Otitis Media, Suppurative / drug therapy*
  • Patient Compliance
  • Penicillin V / administration & dosage
  • Penicillin V / therapeutic use*
  • Prospective Studies
  • Single-Blind Method
  • Sinusitis / drug therapy*
  • Tonsillitis / drug therapy*

Substances

  • Penicillin V