Chemical resolution of +/- -calanolide A, +/- -cordatolide A and their 11-demethyl analogues

Tao Ma; Qi Gao; Zhiwei Chen; Lin Wang; Gang Liu

doi:10.1016/j.bmcl.2007.12.008

Chemical resolution of +/- -calanolide A, +/- -cordatolide A and their 11-demethyl analogues

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1079-83. doi: 10.1016/j.bmcl.2007.12.008. Epub 2007 Dec 10.

Authors

Tao Ma¹, Qi Gao, Zhiwei Chen, Lin Wang, Gang Liu

Affiliation

¹ Department of Synthetic Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2# Nan Wei Road, Beijing 100050, China.

PMID: 18155519
DOI: 10.1016/j.bmcl.2007.12.008

Abstract

The chemical resolution of (+/-)-calanolide A and (+/-)-cordatolide A into their corresponding optically active enantiomers is described. Their inhibitory activities against HIV-1 are tested in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-HIV Agents / chemical synthesis
Anti-HIV Agents / chemistry*
Anti-HIV Agents / pharmacology
Combinatorial Chemistry Techniques
HIV-1 / drug effects
Molecular Structure
Pyranocoumarins / chemical synthesis*
Pyranocoumarins / chemistry*
Pyranocoumarins / pharmacology
Stereoisomerism

Substances

Anti-HIV Agents
Pyranocoumarins
calanolide A