Abstract
Cytokines like interferons (IFNs) play a central role in regulating innate and specific immunities against the pathogens and neoplastic cells. A number of signaling pathways are induced in response to IFN in various cells. One classic mechanism employed by IFNs is the JAK-STAT signaling pathway for inducing cellular responses. Here we describe the non-STAT pathways that participate in IFN-induced responses. In particular, we will focus on the role played by transcription factor C/EBP-beta in mediating these responses.
Publication types
-
Research Support, N.I.H., Extramural
-
Review
MeSH terms
-
Animals
-
CCAAT-Enhancer-Binding Protein-beta* / genetics
-
CCAAT-Enhancer-Binding Protein-beta* / immunology
-
CCAAT-Enhancer-Binding Protein-beta* / metabolism
-
Humans
-
Immunity, Innate
-
Immunotherapy / trends
-
Intercellular Signaling Peptides and Proteins / immunology
-
Intercellular Signaling Peptides and Proteins / metabolism
-
Interferons* / immunology
-
Interferons* / metabolism
-
Intracellular Signaling Peptides and Proteins / immunology*
-
Intracellular Signaling Peptides and Proteins / metabolism*
-
Janus Kinases / immunology
-
MAP Kinase Signaling System / immunology
-
Paracrine Communication / immunology
-
STAT Transcription Factors / immunology
-
Signal Transduction / genetics
-
Signal Transduction / immunology*
Substances
-
CCAAT-Enhancer-Binding Protein-beta
-
Intercellular Signaling Peptides and Proteins
-
Intracellular Signaling Peptides and Proteins
-
STAT Transcription Factors
-
Interferons
-
Janus Kinases