New-onset seizures: a possible association with clonidine?

Frans J M Feron; Jos G M Hendriksen; Joost Nicolai; Johan S H Vles

doi:10.1016/j.pediatrneurol.2007.09.016

New-onset seizures: a possible association with clonidine?

Pediatr Neurol. 2008 Feb;38(2):147-9. doi: 10.1016/j.pediatrneurol.2007.09.016.

Authors

Frans J M Feron¹, Jos G M Hendriksen, Joost Nicolai, Johan S H Vles

Affiliation

¹ Youth Health Care Division, Regional Public Health Institute Maastricht, Department of Child Neurology, University Hospital Maastricht, The Netherlands. frans.feron@ggdzl.nl

PMID: 18206800
DOI: 10.1016/j.pediatrneurol.2007.09.016

Abstract

Clonidine is used as second-line medication for the treatment of attention deficit hyperactivity disorder in children. Product information concerning clonidine reported seizures only after overdosage of clonidine, and the prescription of clonidine has not been contraindicated in patients with known epilepsy. The present case report discusses a possible association of clonidine with new-onset seizures, in the context of status epilepticus in a 9-year-old girl.

Publication types

Case Reports

MeSH terms

Adrenergic alpha-Agonists / adverse effects*
Adrenergic alpha-Agonists / therapeutic use
Anticonvulsants / therapeutic use
Attention Deficit Disorder with Hyperactivity / complications
Attention Deficit Disorder with Hyperactivity / drug therapy
Attention Deficit Disorder with Hyperactivity / etiology
Cerebral Palsy / complications
Child
Clonidine / adverse effects*
Clonidine / therapeutic use
Female
Humans
Seizures / chemically induced*
Seizures / drug therapy
Status Epilepticus / chemically induced
Status Epilepticus / drug therapy

Substances

Adrenergic alpha-Agonists
Anticonvulsants
Clonidine