Anaphylaxis is a severe, life-threatening systemic reaction that can affect all ages. Epinephrine is frequently cited as the first-line and single most important agent in the treatment of severe allergic emergencies. Prompt administration of self-injectable epinephrine by patients and caretakers remains a key component in effective out-of-hospital management. This article will review the technique for self-injectable epinephrine administration in allergic emergencies, including discussion of the available dosages and formulations, indications, as well as other issues related to its use.