Abstract
Accumulation of mutant topoisomerase I cleavage complex can lead to SOS induction and cell death in Escherichia coli. The single-stranded break associated with mutant topoisomerase I cleavage complex is converted to double-stranded break, which then is processed by the RecBCD pathway, followed by association of RecA with the single-stranded DNA.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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DNA Breaks, Double-Stranded
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DNA Breaks, Single-Stranded
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DNA Cleavage
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DNA Topoisomerases, Type I / genetics
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DNA Topoisomerases, Type I / metabolism*
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DNA Topoisomerases, Type II / metabolism
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Escherichia coli / enzymology
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Escherichia coli / genetics*
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism*
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Exodeoxyribonuclease V / genetics
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Exodeoxyribonuclease V / metabolism*
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Rec A Recombinases / genetics
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SOS Response, Genetics*
Substances
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Escherichia coli Proteins
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Rec A Recombinases
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Exodeoxyribonuclease V
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exodeoxyribonuclease V, E coli
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DNA Topoisomerases, Type I
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DNA Topoisomerases, Type II