Abstract
We have analysed the linkage disequilibrium pattern between the promoter TA microsatellite and Single Nucleotide Polymorphism (SNP) haplotypes for the CYBB gene. None of the CYBB SNPs serve as good surrogates for the microsatellite alleles, previously associated with mild malaria. Thus, the candidate (TA)(n) microsatellite should be directly tested in genetic epidemiology studies.
Publication types
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Research Support, N.I.H., Intramural
MeSH terms
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Dinucleotide Repeats / genetics*
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Female
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Humans
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Linkage Disequilibrium / genetics*
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Malaria / epidemiology
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Malaria / genetics*
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Male
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Membrane Glycoproteins / genetics*
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Molecular Epidemiology
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NADPH Oxidase 2
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NADPH Oxidases / genetics*
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Polymorphism, Single Nucleotide*
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Quantitative Trait Loci / genetics*
Substances
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Membrane Glycoproteins
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CYBB protein, human
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NADPH Oxidase 2
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NADPH Oxidases