Characterization of a candidate locus for malaria susceptibility in human populations: a (TA)n microsatellite in the promoter region of the CYBB gene, the gp91 phox subunit of the NADPH oxidase

Int J Immunogenet. 2008 Apr;35(2):107-9. doi: 10.1111/j.1744-313X.2008.00750.x.

Abstract

We have analysed the linkage disequilibrium pattern between the promoter TA microsatellite and Single Nucleotide Polymorphism (SNP) haplotypes for the CYBB gene. None of the CYBB SNPs serve as good surrogates for the microsatellite alleles, previously associated with mild malaria. Thus, the candidate (TA)(n) microsatellite should be directly tested in genetic epidemiology studies.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Dinucleotide Repeats / genetics*
  • Female
  • Humans
  • Linkage Disequilibrium / genetics*
  • Malaria / epidemiology
  • Malaria / genetics*
  • Male
  • Membrane Glycoproteins / genetics*
  • Molecular Epidemiology
  • NADPH Oxidase 2
  • NADPH Oxidases / genetics*
  • Polymorphism, Single Nucleotide*
  • Quantitative Trait Loci / genetics*

Substances

  • Membrane Glycoproteins
  • CYBB protein, human
  • NADPH Oxidase 2
  • NADPH Oxidases