Relapsing Guillain Barré Syndrome and nephrotic syndrome secondary to focal segmental glomerulosclerosis

J Neurol Sci. 2008 Jul 15;270(1-2):184-8. doi: 10.1016/j.jns.2008.01.007. Epub 2008 Mar 5.

Abstract

A 49-year-old man developed simultaneously a Guillain Barré Syndrome (GBS) and a nephrotic syndrome (NS). The patient relapsed twice, despite treatment with intravenous immunoglobulins (IVIg) after a full or partial recovery, and became resistant to IVIg. Renal biopsy revealed focal segmental glomerulosclerosis (FSGS). He responded to plasmapheresis and corticosteroids with simultaneous recovery of his GBS and NS, suggesting a common pathogenesis of the two conditions.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Glomerulosclerosis, Focal Segmental / complications*
  • Glomerulosclerosis, Focal Segmental / therapy
  • Guillain-Barre Syndrome / complications*
  • Guillain-Barre Syndrome / therapy
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Male
  • Middle Aged
  • Nephrotic Syndrome / complications*
  • Nephrotic Syndrome / therapy
  • Plasmapheresis / methods

Substances

  • Adrenal Cortex Hormones
  • Immunoglobulins, Intravenous