Amyloid imaging in aged and young macaques with [11C]PIB and [18F]FDDNP

Synapse. 2008 Jun;62(6):472-5. doi: 10.1002/syn.20508.

Abstract

[11C]PIB and [18F]FDDNP were examined on five aged and five young adult male rhesus macaques using positron emission tomography. Both tracers showed increased accumulation in the striatum, thalamus, cingulate and pons in the aged group. Compared to [11C]PIB, [18F]FDDNP showed higher accumulation in the cortical regions of aged animals as well as young animals. Although [18F]FDDNP may have possible usefulness for imaging, including other proteins, [11C]PIB may be better for amyloid imaging owing to lower non-specific binding.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / physiology*
  • Amyloid / metabolism*
  • Aniline Compounds
  • Animals
  • Benzothiazoles / metabolism*
  • Cerebral Cortex / diagnostic imaging*
  • Cerebral Cortex / metabolism
  • Macaca mulatta
  • Male
  • Nitriles / metabolism*
  • Positron-Emission Tomography / methods
  • Thiazoles

Substances

  • 2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphthyl)ethylidene)malononitrile
  • 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
  • Amyloid
  • Aniline Compounds
  • Benzothiazoles
  • Nitriles
  • Thiazoles