Alachalasins A-G, new cytochalasins from the fungus Stachybotrys Podospora vesticola [corrected]

Yonggang Zhang; Renrong Tian; Shuchun Liu; Xulin Chen; Xingzhong Liu; Yongsheng Che

doi:10.1016/j.bmc.2007.11.042

Alachalasins A-G, new cytochalasins from the fungus Stachybotrys Podospora vesticola [corrected]

Bioorg Med Chem. 2008 Mar 1;16(5):2627-34. doi: 10.1016/j.bmc.2007.11.042.

Authors

Yonggang Zhang¹, Renrong Tian, Shuchun Liu, Xulin Chen, Xingzhong Liu, Yongsheng Che

Affiliation

¹ Key Laboratory of Systematic Mycology and Lichenology, and Center for Bio-Energy and Industrial Biotechnology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.

PMID: 18365343
DOI: 10.1016/j.bmc.2007.11.042

Abstract

Alachalasins A-G (1-7), seven new cytochalasin-type of metabolites, have been isolated from cultures of an isolate of Stachybotrys Podospora vesticola [corrected] The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data, and the absolute configuration of 1 was assigned by application of the modified Mosher method. Alachalasin A (1) displayed inhibitory effect on HIV-1LAI replication in C8166 cells with an EC50 of 8.01 microM; alachalasins D (4) and G (7) showed modest antimicrobial activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemistry
Antifungal Agents / classification
Antifungal Agents / pharmacology
Antiviral Agents / chemistry
Antiviral Agents / classification
Antiviral Agents / pharmacology
Cell Line
Cytochalasins / chemistry*
Cytochalasins / classification
Cytochalasins / pharmacology*
HIV-1 / drug effects
Magnetic Resonance Spectroscopy
Molecular Structure
Stachybotrys / chemistry*

Substances

Antifungal Agents
Antiviral Agents
Cytochalasins