Comprehensive, personalized medication management and pharmacogenetic testing are important existing opportunities to reduce adverse medication events and improve overall healthcare outcomes. A primary barrier to the adoption of personalized pharmacology is the inadequacy of existing patient records, drug interaction tools and the 'interpretation gap'--the lack of physician decision support tools needed to interpret DNA test reports. GeneMedRx, an algorithm-driven, gene-drug interaction software, closes this gap. It helps physicians optimize medication regimens by correlating the genetic makeup of the patient with all the medicines they are taking. Portable personal health records created by GeneMedRx are the core product required for a much-needed comprehensive program of personalized medication management.