Abstract
Two new linear lipopeptides, 1 and 2, and a known compound, curacin D, have been isolated from a marine cyanobacterium, brown Lyngbya polychroa, collected from Hollywood Beach, Fort Lauderdale, Florida. Their planar structures were elucidated by 1D and 2D NMR techniques, and absolute configurations were assigned using chiral HPLC. The new compounds were assigned the trivial names dragonamide C (1) and dragonamide D (2), as their peptide moiety is related to previously reported dragonamides A and B.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Cyanobacteria / chemistry*
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Drug Screening Assays, Antitumor
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Florida
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Humans
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Marine Biology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oligopeptides / chemistry
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Oligopeptides / isolation & purification*
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Oligopeptides / pharmacology
Substances
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Antineoplastic Agents
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Oligopeptides
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dragonamide C
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dragonamide D