Heterogeneity in antisocial behaviours and comorbidity with depressed mood: a behavioural genetic approach

J Child Psychol Psychiatry. 2008 May;49(5):526-34. doi: 10.1111/j.1469-7610.2008.01834.x.

Abstract

Background: Antisocial behaviour is often comorbid with depressed mood but is itself a collection of heterogeneous behaviours. Using a genetically informative design, we examine heterogeneity in antisocial behaviour and overlaps between different forms of antisocial behaviour with depressed mood.

Methods: Data were drawn from the G1219 large-scale community sample containing self-report questionnaire data from 941 twin pairs and 328 sibling-pairs aged 12-21 years.

Results: Inter-correlations among oppositionality, physical aggression and delinquency, and between the antisocial subscales and depressed mood, were mediated by genetic and non-shared environmental influences. Genetic factors generally contributed more to the correlations than the non-shared environment.

Conclusions: These results indicate that many genetic and non-shared environmental influences were common to all the traits studied, but there was also evidence for trait-specific effects.

Publication types

  • Research Support, Non-U.S. Gov't
  • Twin Study

MeSH terms

  • Adolescent
  • Adult
  • Antisocial Personality Disorder / epidemiology*
  • Antisocial Personality Disorder / genetics*
  • Child
  • Depression / diagnosis
  • Depression / epidemiology*
  • Depression / psychology
  • Female
  • Genetic Heterogeneity*
  • Humans
  • Juvenile Delinquency / statistics & numerical data
  • Male
  • Prevalence
  • Severity of Illness Index
  • Social Environment
  • Surveys and Questionnaires
  • Twins / genetics*