Abstract
We describe a Klebsiella oxytoca infection outbreak in a renal transplant unit that involved seven patients. All strains belonged to a single pulsed-field gel electrophoresis pattern and were resistant to amoxicillin-clavulanate, cefuroxime, piperacillin-tazobactam, and aztreonam but susceptible to ceftriaxone, ceftazidime, cefepime, and imipenem. Chromosomal beta-lactamase hyperproduction was caused by a point mutation in the bla(OXY-2) gene promoter region.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Disease Outbreaks*
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Electrophoresis, Gel, Pulsed-Field
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Hospital Units*
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Humans
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Kidney Transplantation*
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Klebsiella Infections / epidemiology*
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Klebsiella Infections / microbiology
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Klebsiella oxytoca / classification
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Klebsiella oxytoca / drug effects
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Klebsiella oxytoca / enzymology*
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Klebsiella oxytoca / genetics
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Microbial Sensitivity Tests
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Point Mutation*
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Promoter Regions, Genetic
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beta-Lactam Resistance
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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beta-Lactamases