Abstract
Parkinson's disease is a neurodegenerative disease in which pigmented midbrain neurons progressively die producing a dopamine (DA) deficit in the striatum which manifests as an akinetic movement disorder. Experimentally induced striatal DA depletion in animals is a valid model of parkinsonism. The capacity of certain substances to damage catecholaminergic neurones has been used for a long time to produce DA deficiency in animals. This unit focuses on methods for inducing parkinsonism using the neurotoxins MPTP and 6-hydroxy dopamine and methods for evaluating the animals. Other models are briefly reviewed.
MeSH terms
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / administration & dosage
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Animals
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Callithrix
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Injections, Intra-Arterial / methods
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Injections, Intravenous / methods
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Levodopa / pharmacology
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MPTP Poisoning / physiopathology
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Macaca fascicularis
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Macaca mulatta
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Mice
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Mice, Inbred C57BL
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Motor Activity / drug effects
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Neurotoxins / toxicity
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Oxidopamine / administration & dosage
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Oxidopamine / toxicity
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Parkinsonian Disorders* / chemically induced
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Parkinsonian Disorders* / physiopathology
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Primates
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Rats
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Rats, Sprague-Dawley
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Severity of Illness Index
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Species Specificity
Substances
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Neurotoxins
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Levodopa
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Oxidopamine
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine