Utility of serum cystatin C as a clinical measure of renal function in dogs

J Am Anim Hosp Assoc. 2008 May-Jun;44(3):131-8. doi: 10.5326/0440131.

Abstract

A human kit for cystatin C determination was evaluated for use with canine sera. A reference range was also established. The association between cystatin C and glomerular filtration rate (GFR) was evaluated in 60 dogs with various diseases, by using exogenous creatinine plasma clearance (ECPC) as a measure of GFR. The correlation between cystatin C and ECPC (correlation coefficient [r] = -0.630; P<0.001) was stronger than the correlation between serum creatinine and ECPC (r = -0.572; P<0.001). Nonrenal diseases (e.g., neoplasia, infection) did not influence serum cystatin C concentration. Test sensitivity was significantly better (P<0.001) for cystatin C (76%) than for creatinine (65%). Specificities for the two tests were 87% and 91%, respectively.

Publication types

  • Comparative Study
  • Validation Study

MeSH terms

  • Animals
  • Creatinine / blood*
  • Cystatin C
  • Cystatins / blood*
  • Dog Diseases / blood
  • Dog Diseases / diagnosis
  • Dog Diseases / physiopathology*
  • Dogs
  • Female
  • Glomerular Filtration Rate / veterinary*
  • Humans
  • Kidney Diseases / diagnosis
  • Kidney Diseases / physiopathology
  • Kidney Diseases / veterinary*
  • Kidney Function Tests / standards
  • Kidney Function Tests / veterinary
  • Male
  • Nephelometry and Turbidimetry / standards
  • Nephelometry and Turbidimetry / veterinary
  • ROC Curve
  • Reagent Kits, Diagnostic / standards
  • Reagent Kits, Diagnostic / veterinary
  • Reference Values
  • Sensitivity and Specificity

Substances

  • CST3 protein, human
  • Cystatin C
  • Cystatins
  • Reagent Kits, Diagnostic
  • Creatinine