Tissue-engineered heart valve prostheses: 'state of the heart'

Regen Med. 2008 May;3(3):399-419. doi: 10.2217/17460751.3.3.399.

Abstract

In this article, we will review the current state of the art in heart valve tissue engineering. We provide an overview of mechanical and biological replacement options, outlining advantages and limitations of each option. Tissue engineering, as a field, is introduced, and specific aspects of valve tissue engineering are discussed (e.g., biomaterials, cells and bioreactors). Technological hurdles, which need to be overcome for advancement of the field, are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Aortic Valve / pathology
  • Biocompatible Materials / chemistry
  • Bioreactors
  • Endothelial Cells / cytology
  • Equipment Design
  • Heart Valve Prosthesis*
  • Humans
  • Models, Anatomic
  • Models, Biological
  • Osteoblasts / cytology
  • Polymers / chemistry
  • Prosthesis Design
  • Stem Cells / cytology
  • Tissue Engineering / methods*

Substances

  • Biocompatible Materials
  • Polymers