Annexin V expression in human placenta is influenced by the carriership of the common haplotype M2

Elena Chinni; Giovanni Luca Tiscia; Donatella Colaizzo; Patrizia Vergura; Maurizio Margaglione; Elvira Grandone

doi:10.1016/j.fertnstert.2007.12.056

Annexin V expression in human placenta is influenced by the carriership of the common haplotype M2

Fertil Steril. 2009 Mar;91(3):940-2. doi: 10.1016/j.fertnstert.2007.12.056. Epub 2008 May 7.

Authors

Elena Chinni¹, Giovanni Luca Tiscia, Donatella Colaizzo, Patrizia Vergura, Maurizio Margaglione, Elvira Grandone

Affiliation

¹ Atherosclerosis and Thrombosis Unit, IRCCS Casa Sollievo della Sofferenza, S Giovanni R, Foggia, Italy. celine.chalas@cch.aphp.fr

PMID: 18462735
DOI: 10.1016/j.fertnstert.2007.12.056

Abstract

In a group of placentas from patients with preeclampsia or fetal growth restriction, reduced annexin V gene expression in those carrying the M2 haplotype was observed. This is the first "ex vivo" demonstration that annexin V gene expression in placentas is dependent on the M2 haplotype.

MeSH terms

Annexin A5 / genetics*
Case-Control Studies
Down-Regulation
Female
Fetal Growth Retardation / genetics*
Genetic Predisposition to Disease
Haplotypes*
Humans
Placenta / chemistry*
Pre-Eclampsia / genetics*
Pregnancy
RNA, Messenger / analysis
Reverse Transcriptase Polymerase Chain Reaction

Substances

Annexin A5
RNA, Messenger