In a representative sample of 2,464 Norwegian adolescents, aged 12-15 years, 7.8% (n= 191) reported reading difficulties (RD). No gender difference was found. Adolescents with RD were compared to classmates on psychosocial variables. In univariate analysis, RD adolescents report higher levels of depressive symptoms, more school stress, worried more about going to school, had lower school grades and lower attachment to parents than those without RD. They also scored lower on Global Self-worth and on Social Acceptance scales. Further, they reported reduced levels of psycho-functioning during the previous year because of mental health problems, they had received more help and had used more medication for such problems. In a multivariate logistic regression analysis, receiving help for mental health problems and reduced psycho-functioning showed the strongest associations with student RD status. No gender interactions were found. The study demonstrated important differences between adolescents with and without RD.