Abstract
We review the role of E-cadherin in cancer progression, and its therapeutic restoration as a strategy to suppress metastasis. We subsequently discuss E-cadherin upregulating drugs, proposing a schema for restoring E-cadherin by targeting its epigenetic and transcriptional regulators. These pathways will likely provide significant future treatment breakthroughs against cancer metastasis.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use*
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Cadherins / drug effects
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Cadherins / genetics
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Cadherins / metabolism*
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Gene Expression Regulation / drug effects
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Humans
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Neoplasms / drug therapy*
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Neoplasms / metabolism
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Transcription, Genetic / drug effects
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Transcription, Genetic / genetics
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Up-Regulation / drug effects*
Substances
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Antineoplastic Agents
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Cadherins