E-cadherin upregulation as a therapeutic goal in cancer treatment

Mini Rev Med Chem. 2008 May;8(5):496-518. doi: 10.2174/138955708784223521.

Abstract

We review the role of E-cadherin in cancer progression, and its therapeutic restoration as a strategy to suppress metastasis. We subsequently discuss E-cadherin upregulating drugs, proposing a schema for restoring E-cadherin by targeting its epigenetic and transcriptional regulators. These pathways will likely provide significant future treatment breakthroughs against cancer metastasis.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Cadherins / drug effects
  • Cadherins / genetics
  • Cadherins / metabolism*
  • Gene Expression Regulation / drug effects
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / metabolism
  • Transcription, Genetic / drug effects
  • Transcription, Genetic / genetics
  • Up-Regulation / drug effects*

Substances

  • Antineoplastic Agents
  • Cadherins