Abstract
Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of beta-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of beta-defensin expression compared with other AMP genes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Computational Biology / methods*
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Humans
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Membrane Proteins / metabolism*
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Molecular Sequence Data
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Protein Precursors / chemistry
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Protein Precursors / metabolism
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Protein Processing, Post-Translational*
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Protein Sorting Signals
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Sequence Alignment
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Serine Endopeptidases / metabolism*
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beta-Defensins / chemistry
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beta-Defensins / metabolism*
Substances
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Membrane Proteins
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Protein Precursors
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Protein Sorting Signals
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beta-Defensins
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Serine Endopeptidases
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type I signal peptidase