Colorectal cancer is the second leading cause of deaths due to cancer for both men and women in the United States. Screening promotes the early detection of colorectal cancer and reduces the morbidity and mortality rates. Worksite wellness programs are an effective way to promote colorectal cancer prevention and screening awareness and compliance with the American Cancer Society's screening guidelines, and they provide several advantages from the perspectives of the employees, employers, and nurses. This article explains how to orchestrate key personnel to increase colorectal cancer awareness in the worksite. A review of evidence-based literature is utilized to maximize the effectiveness of these worksite education sessions. The goals for the worksite employees are to resolve their individual barriers through education, to commit to colorectal cancer screening and prevention, and to feel a sense of obligation to follow through on their plans.