A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands

Bioorg Med Chem Lett. 2008 Jul 15;18(14):3929-31. doi: 10.1016/j.bmcl.2008.06.030. Epub 2008 Jun 13.

Abstract

A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands is reported.

MeSH terms

  • Chemistry, Pharmaceutical / methods
  • Drug Design
  • Humans
  • Indoles / chemistry*
  • Inhibitory Concentration 50
  • Kinetics
  • Ligands
  • Models, Chemical
  • Molecular Structure
  • Protein Binding / drug effects
  • Receptors, Serotonin / chemistry*
  • Receptors, Serotonin / metabolism
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tryptamines / chemistry

Substances

  • Indoles
  • Ligands
  • Receptors, Serotonin
  • Tryptamines
  • serotonin 6 receptor