Rab5 and rac team up in cell motility

Cell. 2008 Jul 11;134(1):18-20. doi: 10.1016/j.cell.2008.06.039.

Abstract

Cell motility requires actin assembly mediated by Rac, a Rho family GTPase. In this issue, Palamidessi et al. (2008) show that Rab5-directed trafficking of Rac to the cell membrane is required for Rac-mediated actin assembly. Trafficking of Rac may influence the mode of cell migration during morphogenesis and cancer metastasis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Movement*
  • Cell Shape
  • Hepatocyte Growth Factor / metabolism
  • Humans
  • Models, Biological
  • Morphogenesis
  • Neoplasm Metastasis
  • Proto-Oncogene Proteins c-akt / metabolism*
  • rab5 GTP-Binding Proteins / metabolism*

Substances

  • Hepatocyte Growth Factor
  • Proto-Oncogene Proteins c-akt
  • rab5 GTP-Binding Proteins