Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns

J Rheumatol. 2008 Aug;35(8):1609-12. Epub 2008 Jul 15.

Abstract

Objective: To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS).

Methods: A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed.

Results: In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses.

Conclusion: CD14 and TLR4 showed an association with AS in the Finns only.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Cohort Studies
  • Female
  • Finland
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Lipopolysaccharide Receptors / genetics*
  • Male
  • Odds Ratio
  • Polymorphism, Single Nucleotide / genetics*
  • Spondylitis, Ankylosing / genetics*
  • Toll-Like Receptor 4 / genetics*
  • United Kingdom

Substances

  • Lipopolysaccharide Receptors
  • TLR4 protein, human
  • Toll-Like Receptor 4