Effect of pancragen on blood glucose level, capillary permeability and adhesion in rats with experimental diabetes mellitus

V Kh Khavinson; N A Gavrisheva; V V Malinin; S G Chefu; E L Trofimov

doi:10.1007/s10517-007-0377-3

Effect of pancragen on blood glucose level, capillary permeability and adhesion in rats with experimental diabetes mellitus

Bull Exp Biol Med. 2007 Oct;144(4):559-62. doi: 10.1007/s10517-007-0377-3.

Authors

V Kh Khavinson¹, N A Gavrisheva, V V Malinin, S G Chefu, E L Trofimov

Affiliation

¹ St. Petersburg Institute of Bioregulation and Gerontology, NorthWestern Division of Russian Academy of Medical Sciences.

PMID: 18642713
DOI: 10.1007/s10517-007-0377-3

Abstract

The effects of tetrapeptide pancragen (Lys-Glu-Asp-Trp-NH2) on blood glucose level and permeability and adhesion of mesenteric capillaries were studied in Wistar rats with experimental streptozotocin-induced diabetes mellitus. Oral pancragen produced a pronounced hypoglycemic effect during treatment. Intramuscular pancragen normalized the adhesion of mesenteric capillary endothelium, but did not modify capillary permeability. The results indicate homeostatic and endothelioprotective effects of pancragen during the early period of diabetes mellitus.

MeSH terms

Administration, Oral
Animals
Blood Glucose / analysis*
Capillary Permeability / drug effects*
Cell Adhesion / drug effects
Diabetes Mellitus, Experimental / blood
Diabetes Mellitus, Experimental / chemically induced
Diabetes Mellitus, Experimental / drug therapy*
Injections, Intramuscular
Male
Mesentery / blood supply
Oligopeptides / administration & dosage
Oligopeptides / pharmacology*
Rats
Rats, Wistar
Streptozocin

Substances

Blood Glucose
Oligopeptides
lysyl-glutamyl-aspartyl-tryptophan
lysyl-glutamyl-aspartyl-tryptophanamide
Streptozocin