Abstract
Azathioprine is an immunosuppressive and steroid-sparing purine analogue, used in the treatment of several autoimmune diseases. In multiple sclerosis, available evidence suggests that oral azathioprine reduces relapse rates, provides a slight benefit on disability, and reduces new inflammatory lesions. Here, we focus on molecular mechanisms of Azathioprine and on its usefulness in multiple sclerosis.
MeSH terms
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Antibodies, Monoclonal / pharmacology
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Antibodies, Monoclonal, Humanized
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Azathioprine / pharmacology*
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Chemistry, Pharmaceutical / methods*
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Cyclophosphamide / pharmacology
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Drug Design
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Fingolimod Hydrochloride
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Humans
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Immunologic Factors / pharmacology
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Immunosuppressive Agents / pharmacology*
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Methotrexate / pharmacology
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Methyltransferases / metabolism
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Mitoxantrone / pharmacology
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Models, Chemical
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Multiple Sclerosis / drug therapy*
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Multiple Sclerosis, Relapsing-Remitting / drug therapy
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Natalizumab
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Propylene Glycols / pharmacology
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Sphingosine / analogs & derivatives
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Sphingosine / pharmacology
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Immunologic Factors
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Immunosuppressive Agents
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Natalizumab
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Propylene Glycols
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Cyclophosphamide
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Mitoxantrone
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Methyltransferases
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thiopurine methyltransferase
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Fingolimod Hydrochloride
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Azathioprine
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Sphingosine
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Methotrexate