Complete follicular development and recovery of ovarian function of frozen-thawed, autotransplanted caprine ovarian cortex

Regiane R Santos; Hiemke M Knijn; Peter L A M Vos; Christine H Y Oei; Thijs van Loon; Ben Colenbrander; Bart M Gadella; Rob van den Hurk; Bernard A J Roelen

doi:10.1016/j.fertnstert.2008.07.018

Complete follicular development and recovery of ovarian function of frozen-thawed, autotransplanted caprine ovarian cortex

Fertil Steril. 2009 Apr;91(4 Suppl):1455-8. doi: 10.1016/j.fertnstert.2008.07.018. Epub 2008 Aug 22.

Authors

Regiane R Santos¹, Hiemke M Knijn, Peter L A M Vos, Christine H Y Oei, Thijs van Loon, Ben Colenbrander, Bart M Gadella, Rob van den Hurk, Bernard A J Roelen

Affiliation

¹ Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

PMID: 18722611
DOI: 10.1016/j.fertnstert.2008.07.018

Abstract

Frozen-thawed ovarian cortical fragments (1 mm(3)) were autotransplanted to the uterus of completely ovariectomized goats. The grafts developed preovulatory follicles, accompanied by estrous behavior and a rise in plasma E(2) levels, demonstrating successful cryopreservation and transplantation.

MeSH terms

Animals
Cryopreservation / methods*
Estrogens / blood
Estrus / blood
Estrus / physiology
Female
Goats
Models, Animal
Ovarian Follicle / growth & development*
Ovarian Follicle / physiology
Ovariectomy
Ovary / physiology*
Progesterone / blood
Testosterone / blood
Transplantation, Autologous / methods*

Substances

Estrogens
Testosterone
Progesterone