Unveiling novel forms of hippocampal synaptic plasticity with microelectrode arrays

J Integr Neurosci. 2008 Jun;7(2):249-70. doi: 10.1142/s0219635208001800.

Abstract

In this report, we elucidate by use of microelectrode arrays novel forms of long-term depression and potentiation in the hippocampus which are triggered by low frequency afferent stimulation and which rely on the activation of metabotropic glutamate receptor of the fifth subtype (mGlu5 receptor).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Animals
  • Animals, Newborn
  • Brain Mapping*
  • Cyclic AMP / pharmacology
  • Dose-Response Relationship, Radiation
  • Electric Stimulation / methods
  • Enzyme Inhibitors / pharmacology
  • Excitatory Amino Acid Agonists / pharmacology
  • Excitatory Amino Acid Antagonists / pharmacology
  • Female
  • Hippocampus / cytology*
  • In Vitro Techniques
  • Male
  • Membrane Potentials / drug effects
  • Membrane Potentials / physiology
  • Membrane Potentials / radiation effects
  • Microelectrodes*
  • Mitogen-Activated Protein Kinase Kinases / metabolism
  • Models, Neurological
  • Neuronal Plasticity / drug effects
  • Neuronal Plasticity / physiology*
  • Neuronal Plasticity / radiation effects
  • Neurons / cytology*
  • Neurons / physiology
  • Neurons / radiation effects
  • Patch-Clamp Techniques
  • Rats
  • Rats, Sprague-Dawley
  • Sodium Channel Blockers / pharmacology
  • Synapses / drug effects
  • Synapses / physiology*
  • Synapses / radiation effects
  • Tetrodotoxin / pharmacology

Substances

  • Enzyme Inhibitors
  • Excitatory Amino Acid Agonists
  • Excitatory Amino Acid Antagonists
  • Sodium Channel Blockers
  • Tetrodotoxin
  • Cyclic AMP
  • Mitogen-Activated Protein Kinase Kinases