Inter- and intraobserver variation in HR-CTV contouring: intercomparison of transverse and paratransverse image orientation in 3D-MRI assisted cervix cancer brachytherapy

Radiother Oncol. 2008 Nov;89(2):164-71. doi: 10.1016/j.radonc.2008.07.030. Epub 2008 Sep 12.

Abstract

Aim: To analyze agreement between target volumes, delineated by two observers on transverse (T) and paratransverse (perpendicular to the long cervical axis - PT) MR images for cervix cancer brachytherapy.

Materials and methods: In 13 patients, High Risk-CTV (HR-CTV) was outlined by two observers in T and PT MR image plane, respecting the GYN GEC-ESTRO recommendations for 3D-image based cervix cancer brachytherapy [1]. Contouring time was measured. HR-CTV sizes were compared, and conformity index (CI) was assessed. Interobserver variations in contour-extent along eight radial directions were compared between delineation planes. After applying a standard treatment plan, an intercomparison of DVH-parameters V100, D90, and D100 for the HR-CTV was carried out.

Results: Contouring time was slightly longer in T than PT orientation. Interplane CI did not differ significantly between observers (0.72 vs. 0.71), nor did the interobserver CI between planes (0.79 vs. 0.78). Variations in contour-extent between different radial directions and interplane deviations in DVH parameters were non-significant.

Conclusion: Contouring in PT, as compared to T plane, allows for a "circumferential view of the cervix" and facilitates comprehensive understanding of spatial relations between the applicator and patho-anatomical structures. It is marked by a lower contouring difficulty and leads to a comparable outcome in terms of DVH parameters. Interobserver inconsistencies can be minimized by systematic training and following the published recommendations.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brachytherapy / methods*
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional*
  • Magnetic Resonance Imaging, Interventional
  • Observer Variation
  • Radiography, Interventional
  • Radiotherapy Planning, Computer-Assisted*
  • Radiotherapy, Conformal
  • Statistics, Nonparametric
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Uterine Cervical Neoplasms / radiotherapy*