Genetic variation of Omi/HtrA2 and Parkinson's disease

Parkinsonism Relat Disord. 2008 Nov;14(7):539-43. doi: 10.1016/j.parkreldis.2008.08.003. Epub 2008 Sep 14.

Abstract

Variants in the Omi/HtrA2 gene have been nominated as a cause of Parkinson's disease. This sequencing study of Omi/HtrA2 in 95 probands with apparent autosomal dominant inheritance of Parkinson's disease did not identify any pathogenic mutations. In addition, there was no association between common variations in the Omi/HtrA2 gene and susceptibility to Parkinson's disease in any of our four patient-control series (n=2373). Taken together our results do not support a role for Omi/HtrA2 variants in the pathogenesis of Parkinson's disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Chi-Square Distribution
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genetic Testing
  • Genetic Variation / genetics*
  • High-Temperature Requirement A Serine Peptidase 2
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Mitochondrial Proteins / genetics*
  • Molecular Sequence Data
  • Parkinson Disease / genetics*
  • Serine Endopeptidases / genetics*

Substances

  • Mitochondrial Proteins
  • Serine Endopeptidases
  • HTRA2 protein, human
  • High-Temperature Requirement A Serine Peptidase 2