Feasibility of allogeneic hematopoietic stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma

Leuk Lymphoma. 2008 Oct;49(10):1893-8. doi: 10.1080/10428190802270902.

Abstract

The transformation of follicular lymphoma (FL) to high-grade histology occurs in up to 70% of FL patients. Studies reporting outcomes of transformed FL patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are scant. Eight FL patients with histologically confirmed transformation to diffuse large B-cell lymphoma underwent HSCT at our institution. The median age was 56 years (range 44-63 years). Median follow-up is 60 months. Progression free survival and overall survival at 4-years for patients undergoing allogeneic HSCT is 56% and 66%, respectively. Four patients developed grade II-IV acute GVHD, whereas four patients had extensive chronic GVHD. Day 100 and overall non-relapse mortality rate was 12.5% and 25%, respectively. Allogeneic HSCT appears feasible in patients with transformed FL and is associated with acceptable treatment-related mortality and low relapse rates.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Cell Transformation, Neoplastic
  • Feasibility Studies
  • Female
  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation / methods*
  • Humans
  • Lymphoma, Follicular / pathology*
  • Lymphoma, Large B-Cell, Diffuse / etiology
  • Lymphoma, Large B-Cell, Diffuse / mortality
  • Lymphoma, Large B-Cell, Diffuse / therapy*
  • Male
  • Middle Aged
  • Salvage Therapy
  • Survival Analysis
  • Transplantation Conditioning / methods
  • Transplantation, Homologous