Chongmyungtang attenuates kainic acid-induced seizure and mortal effect in the mouse

K J Jang; K H Lee; S L Kim; D Y Choi; B K Park; D H Im; Y J Cho; W K Jhoo; H C Kim

doi:10.1007/BF02976204

Chongmyungtang attenuates kainic acid-induced seizure and mortal effect in the mouse

Arch Pharm Res. 1997 Aug;20(4):375-8. doi: 10.1007/BF02976204.

Authors

K J Jang¹, K H Lee, S L Kim, D Y Choi, B K Park, D H Im, Y J Cho, W K Jhoo, H C Kim

Affiliation

¹ Boryung Pharmaceutical Central Research Institute, 435-050, Kunpo, Korea.

PMID: 18975183
DOI: 10.1007/BF02976204

Abstract

TheChongmyungtang (CMT; the combination ofAcorus gramineus, polygala tenuifolia andPoria cocos) has been recognized to possess the preventive effect against several neurologic disorders in human. In this study, we examined the effect of CMT on the three parameters associated with kainic acid (KA)-induced neurotoxicities; seizure/mortality, increased fos-related antigen (FRA) and glial fibrillary acidic protein (GFAP) expression. KA induced vigorous convulsions lasting 4-6 hr. Pretreatments with CMT before KA injection significantly reduced the seizure intensity as well as the mortality. CMT pretreatments also attenuated the KA-induced increase in FRA/GFAP expression in the hippocampus. These results suggest that CMT has a neuroprotective effect against KA-induced neurotoxicities.