New cell or new cycle?

Genes Dev. 2008 Nov 1;22(21):2908-13. doi: 10.1101/gad.1740808.

Abstract

In mammals, trophoblast giant (TG) cell differentiation is characterized by a physiological endoreduplication, resulting in genome size augmentation. A recent study by Ullah and colleagues (pp. 3024-3036), published in this issue of Genes & Development, now elucidates the role of the cyclin-dependent kinase inhibitors (CKIs), p21 and p57, in mammalian endocycle regulation.

Publication types

  • Comment

MeSH terms

  • Animals
  • CDC2 Protein Kinase / antagonists & inhibitors
  • CDC2 Protein Kinase / physiology*
  • Cell Cycle / physiology*
  • Cell Cycle Proteins / physiology*
  • Cell Differentiation / physiology
  • Cyclin-Dependent Kinase Inhibitor p57 / physiology*
  • Giant Cells / cytology*
  • Giant Cells / physiology
  • Trophoblasts / cytology*
  • Trophoblasts / physiology
  • p21-Activated Kinases / physiology

Substances

  • Cell Cycle Proteins
  • Cyclin-Dependent Kinase Inhibitor p57
  • p21-Activated Kinases
  • CDC2 Protein Kinase