Abstract
In mammals, trophoblast giant (TG) cell differentiation is characterized by a physiological endoreduplication, resulting in genome size augmentation. A recent study by Ullah and colleagues (pp. 3024-3036), published in this issue of Genes & Development, now elucidates the role of the cyclin-dependent kinase inhibitors (CKIs), p21 and p57, in mammalian endocycle regulation.
MeSH terms
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Animals
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CDC2 Protein Kinase / antagonists & inhibitors
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CDC2 Protein Kinase / physiology*
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Cell Cycle / physiology*
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Cell Cycle Proteins / physiology*
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Cell Differentiation / physiology
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Cyclin-Dependent Kinase Inhibitor p57 / physiology*
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Giant Cells / cytology*
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Giant Cells / physiology
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Trophoblasts / cytology*
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Trophoblasts / physiology
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p21-Activated Kinases / physiology
Substances
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Cell Cycle Proteins
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Cyclin-Dependent Kinase Inhibitor p57
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p21-Activated Kinases
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CDC2 Protein Kinase