Purpose of investigation: Primary squamous cell carcinoma of the endometrium (PSCCE) is an extremely rare entity.
Methods: We present the clinical and pathological findings of a 90-year-old patient with International Federation of Gynecologists and Obstetricians Stage 1C primary squamous cell carcinoma of the endometrium who was treated with hysterectomy and bilateral salpingooophorectomy.
Results: The patient declined adjuvant therapy and continues on progestin therapy. She was free of disease at a one-year follow-up visit. In addition, the current literature is discussed in this report.
Conclusions: Since primary squamous cell carcinoma of the endometrium is so infrequent, it is difficult to evaluate the efficacy of adjuvant therapy. Although the prognosis historically has been reported as poor compared to endometrial adenocarcinoma, the prognosis does seem to be dependent on the surgical stage at diagnosis rather than on the adjuvant treatment component.