Abstract
A 55-year-old woman with melasma develops biopsy-proved exogenous ochronosis in the setting of prolonged topical hydroquinone use. A limited number of similar reports exist in the US literature and are the basis for an FDA call to review hydroquinone-based products. This case underscores the difficult therapeutic dilemma which this diagnosis presents to dermatologists.
MeSH terms
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Dermatologic Agents / adverse effects*
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Diagnosis, Differential
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Facial Dermatoses / chemically induced*
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Facial Dermatoses / diagnosis
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Facial Dermatoses / pathology
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Female
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Humans
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Hydroquinones / adverse effects*
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Melanosis / drug therapy*
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Middle Aged
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Ochronosis / chemically induced*
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Ochronosis / diagnosis
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Ochronosis / pathology
Substances
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Dermatologic Agents
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Hydroquinones
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hydroquinone