The assessment of functional and cognitive efficiency of acute brain injured patients represents a relevant innovation in the rehabilitative approach to stroke patients. Indeed, the identification of severe cognitive difficulties early in the recovery process can be an important prognostic factor for the evolution of the disorders themselves. The aim of the present study was to describe a new diagnostic tool that rapidly assesses the cognitive efficiency of acute patients suffering from a cerebral vascular accident. The Brief Neuropsychological Screening (BNS) has been designed for the detection of either the presence or absence of damage in different cognitive areas, with particular emphasis to those most frequently occurring after a stroke, such as aphasia, apraxia, agnosia or eminattention. Data from 250 normal adult subjects and from a group of 150 acute cerebrovascular inpatients are also presented that confirm the validity of the BNS in discriminating acute patients affected by cognitive impairments from those free of cognitive disruption, and supports its prognostic value in predicting cognitive recovery over time.