Micropatterned surfaces with covalently grafted unsymmetrical polyoxometalate-hybrid clusters lead to selective cell adhesion

Yu-Fei Song; Nicola McMillan; De-Liang Long; Struan Kane; Jakob Malm; Mathis O Riehle; Chullikkattil P Pradeep; Nikolaj Gadegaard; Leroy Cronin

doi:10.1021/ja807091v

Micropatterned surfaces with covalently grafted unsymmetrical polyoxometalate-hybrid clusters lead to selective cell adhesion

J Am Chem Soc. 2009 Feb 4;131(4):1340-1. doi: 10.1021/ja807091v.

Authors

Yu-Fei Song¹, Nicola McMillan, De-Liang Long, Struan Kane, Jakob Malm, Mathis O Riehle, Chullikkattil P Pradeep, Nikolaj Gadegaard, Leroy Cronin

Affiliation

¹ WestCHEM Department of Chemistry, Joseph Black Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ UK.

PMID: 19138073
DOI: 10.1021/ja807091v

Abstract

Mn-Anderson based polyoxometalate clusters with different terminal groups have been patterned successfully onto self-assembled monolayer (SAM) using microcontact printing. Studies of the interactions between the designed SAMs and human fibroblast (hTERT-BJ1) cells have been reported, and it was observed that cells attach and spread efficiently for monolayer presenting a terminal aromatic pyrene platform with a polyoxometalate Mn-Anderson cluster as linker, demonstrating the crucial role played by the polyoxometalate metal oxide cluster as an intermediary in cell adhesion to the surface.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Adhesion
Cell Line
Humans
Microscopy, Electron, Scanning
Models, Molecular
Molecular Structure
Stereoisomerism
Surface Properties
Tungsten Compounds / chemistry*

Substances

Tungsten Compounds
polyoxometalate I